BRD-K25737009_-666_SKMEL1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K25737009_-666_SKMEL1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AEBP1 AE binding protein 1
ANXA1 annexin A1
ARG2 arginase 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
C9ORF3 chromosome 9 open reading frame 3
CCL5 chemokine (C-C motif) ligand 5
CES1 carboxylesterase 1
COL16A1 collagen, type XVI, alpha 1
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAP death-associated protein
DHDDS dehydrodolichyl diphosphate synthase
DLC1 DLC1 Rho GTPase activating protein
DMD dystrophin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP5 insulin-like growth factor binding protein 5
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL17RB interleukin 17 receptor B
IL6 interleukin 6
ISLR immunoglobulin superfamily containing leucine-rich repeat
JUNB jun B proto-oncogene
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LUM lumican
LYZ lysozyme
MGP matrix Gla protein
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SDC4 syndecan 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SRGN serglycin
TAGLN2 transgelin 2
TPD52L1 tumor protein D52-like 1
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZFAND1 zinc finger, AN1-type domain 1

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
AREG amphiregulin
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AUTS2 autism susceptibility candidate 2
B3GNT1
BTN3A2 butyrophilin, subfamily 3, member A2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHERP calcium homeostasis endoplasmic reticulum protein
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM57A family with sequence similarity 57, member A
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GJA1 gap junction protein, alpha 1, 43kDa
GPC4 glypican 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
KRT10 keratin 10, type I
LOX lysyl oxidase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MEGF9 multiple EGF-like-domains 9
MLEC malectin
MREG melanoregulin
MTCL1 microtubule crosslinking factor 1
NSG1 neuron specific gene family member 1
NUSAP1 nucleolar and spindle associated protein 1
PDGFD platelet derived growth factor D
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PLCL2 phospholipase C-like 2
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SGCE sarcoglycan, epsilon
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TRIB1 tribbles pseudokinase 1
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
VCAN versican