BRD-K25737009_-666_OV7_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K25737009_-666_OV7_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA10 annexin A10
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCAS1 breast carcinoma amplified sequence 1
BLNK B-cell linker
BTG2 BTG family, member 2
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CPD carboxypeptidase D
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IL6 interleukin 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIF5C kinesin family member 5C
LAGE3 L antigen family, member 3
LEFTY1 left-right determination factor 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MICALL1 MICAL-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NEFL neurofilament, light polypeptide
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RIPK2 receptor-interacting serine-threonine kinase 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TMEM243 transmembrane protein 243, mitochondrial
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VAV3 vav 3 guanine nucleotide exchange factor
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
APOA2 apolipoprotein A-II
ARL4C ADP-ribosylation factor-like 4C
B3GNT1
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD1E CD1e molecule
CD8A CD8a molecule
CDC20 cell division cycle 20
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CELF2 CUGBP, Elav-like family member 2
CLIC5 chloride intracellular channel 5
CNN3 calponin 3, acidic
COLEC12 collectin sub-family member 12
CTSZ cathepsin Z
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFNB2 ephrin-B2
FAM65B family with sequence similarity 65, member B
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FBXO21 F-box protein 21
FDPS farnesyl diphosphate synthase
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
HMGB3 high mobility group box 3
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LDOC1 leucine zipper, down-regulated in cancer 1
LTBP1 latent transforming growth factor beta binding protein 1
LYPD1 LY6/PLAUR domain containing 1
MRPS16 mitochondrial ribosomal protein S16
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT2A metallothionein 2A
MTERF3 mitochondrial transcription termination factor 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NREP neuronal regeneration related protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUSAP1 nucleolar and spindle associated protein 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
POSTN periostin, osteoblast specific factor
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PXDN peroxidasin
RBP1 retinol binding protein 1, cellular
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPP1 secreted phosphoprotein 1
SYBU syntabulin (syntaxin-interacting)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VGLL4 vestigial-like family member 4