BRD-K25737009_-666_NCIH2073_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K25737009_-666_NCIH2073_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
C5 complement component 5
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CREB3L2 cAMP responsive element binding protein 3-like 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
FST follistatin
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GK glycerol kinase
GPM6B glycoprotein M6B
GSN gelsolin
H1F0 H1 histone family, member 0
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
JAM3 junctional adhesion molecule 3
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEF2C myocyte enhancer factor 2C
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICALL1 MICAL-like 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
NBPF10 neuroblastoma breakpoint family, member 10
NEFL neurofilament, light polypeptide
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM4 PDZ and LIM domain 4
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS3 protease, serine, 3
PRSS8 protease, serine, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB2A RAB2A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RPS5 ribosomal protein S5
RRAD Ras-related associated with diabetes
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SRPX sushi-repeat containing protein, X-linked
TJP2 tight junction protein 2
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VNN1 vanin 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
AURKA aurora kinase A
B3GNT1
CAV2 caveolin 2
CCDC47 coiled-coil domain containing 47
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CFI complement factor I
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFR3A EFR3 homolog A (S. cerevisiae)
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
IDI1 isopentenyl-diphosphate delta isomerase 1
IPO13 importin 13
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0232 KIAA0232
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBH limb bud and heart development
LMNB1 lamin B1
MYH10 myosin, heavy chain 10, non-muscle
NCAPG2 non-SMC condensin II complex, subunit G2
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
OXTR oxytocin receptor
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCTP phosphatidylcholine transfer protein
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP prolactin-induced protein
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRSS23 protease, serine, 23
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SEPHS1 selenophosphate synthetase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TBC1D4 TBC1 domain family, member 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNDC9 thioredoxin domain containing 9
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNG uracil-DNA glycosylase
UPK1B uroplakin 1B
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
XPO7 exportin 7