BRD-K25737009_-666_NCIH1694_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K25737009_-666_NCIH1694_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CA2 carbonic anhydrase II
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC2 chloride intracellular channel 2
COL15A1 collagen, type XV, alpha 1
CTSG cathepsin G
DDIT4 DNA-damage-inducible transcript 4
EREG epiregulin
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
HIST1H2BG histone cluster 1, H2bg
IL6 interleukin 6
KRT20 keratin 20, type I
LOX lysyl oxidase
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MMP12 matrix metallopeptidase 12
MXRA5 matrix-remodelling associated 5
NARFL nuclear prelamin A recognition factor-like
NPR3 natriuretic peptide receptor 3
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHACTR2 phosphatase and actin regulator 2
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RAB25 RAB25, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
SATB2 SATB homeobox 2
SH3YL1 SH3 and SYLF domain containing 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRGN serglycin
STAR steroidogenic acute regulatory protein
STC2 stanniocalcin 2
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TCL1B T-cell leukemia/lymphoma 1B
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BAG5 BCL2-associated athanogene 5
BCHE butyrylcholinesterase
C7 complement component 7
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CELF2 CUGBP, Elav-like family member 2
CERK ceramide kinase
CHRDL1 chordin-like 1
COPS7A COP9 signalosome subunit 7A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DES desmin
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF5A eukaryotic translation initiation factor 5A
GNLY granulysin
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
HIST1H2BD histone cluster 1, H2bd
HMGN3 high mobility group nucleosomal binding domain 3
HN1 hematological and neurological expressed 1
IFI44L interferon-induced protein 44-like
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
ISOC1 isochorismatase domain containing 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAP3 leucine aminopeptidase 3
LGALS1 lectin, galactoside-binding, soluble, 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MSLN mesothelin
MTA1 metastasis associated 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDLIM4 PDZ and LIM domain 4
PEG10 paternally expressed 10
PLBD1 phospholipase B domain containing 1
PLN phospholamban
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PUF60 poly-U binding splicing factor 60KDa
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAI14 retinoic acid induced 14
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SVIL supervillin
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D31 TBC1 domain family, member 31
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TSPAN7 tetraspanin 7
UGDH UDP-glucose 6-dehydrogenase
WT1 Wilms tumor 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF423 zinc finger protein 423