BRD-K25737009_-666_MDST8_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K25737009_-666_MDST8_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMPD3 adenosine monophosphate deaminase 3
ANKRD12 ankyrin repeat domain 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATG12 autophagy related 12
BANK1 B-cell scaffold protein with ankyrin repeats 1
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
C2CD2 C2 calcium-dependent domain containing 2
C6ORF48 chromosome 6 open reading frame 48
CALCOCO2 calcium binding and coiled-coil domain 2
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLIC4 chloride intracellular channel 4
COG5 component of oligomeric golgi complex 5
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CRYAB crystallin, alpha B
CSNK1A1 casein kinase 1, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLG1 discs, large homolog 1 (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
EPHA3 EPH receptor A3
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FHL1 four and a half LIM domains 1
FMOD fibromodulin
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FXR1 fragile X mental retardation, autosomal homolog 1
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
IARS isoleucyl-tRNA synthetase
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IQGAP1 IQ motif containing GTPase activating protein 1
JUN jun proto-oncogene
KIAA0125 KIAA0125
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LITAF lipopolysaccharide-induced TNF factor
LMO4 LIM domain only 4
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MICALL1 MICAL-like 1
MOCOS molybdenum cofactor sulfurase
MT1F metallothionein 1F
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NGRN neugrin, neurite outgrowth associated
NPY1R neuropeptide Y receptor Y1
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PHGDH phosphoglycerate dehydrogenase
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOH ras homolog family member H
RPL39L ribosomal protein L39-like
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TFF1 trefoil factor 1
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TPBG trophoblast glycoprotein
TPM4 tropomyosin 4
TRAF5 TNF receptor-associated factor 5
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VLDLR very low density lipoprotein receptor
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
XYLT1 xylosyltransferase I
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANOS1 anosmin 1
C1ORF116 chromosome 1 open reading frame 116
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD1E CD1e molecule
CLCA2 chloride channel accessory 2
CPA3 carboxypeptidase A3 (mast cell)
CST6 cystatin E/M
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5A cytochrome b5 type A (microsomal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTL1 cytokine-like 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DUT deoxyuridine triphosphatase
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
EXT1 exostosin glycosyltransferase 1
FASN fatty acid synthase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
KIAA0355 KIAA0355
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LYPD1 LY6/PLAUR domain containing 1
LYST lysosomal trafficking regulator
MSMO1 methylsterol monooxygenase 1
MXRA5 matrix-remodelling associated 5
NSDHL NAD(P) dependent steroid dehydrogenase-like
NSG1 neuron specific gene family member 1
PBX3 pre-B-cell leukemia homeobox 3
PDPN podoplanin
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLK1 polo-like kinase 1
PRSS23 protease, serine, 23
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRI sorcin
SRSF11 serine/arginine-rich splicing factor 11
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
VAMP8 vesicle-associated membrane protein 8