BRD-K25737009_-666_HT29_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

281 genes differentially expressed following the BRD-K25737009_-666_HT29_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARF4 ADP-ribosylation factor 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CLDN7 claudin 7
CLIC4 chloride intracellular channel 4
COL16A1 collagen, type XVI, alpha 1
COL9A3 collagen, type IX, alpha 3
CREB5 cAMP responsive element binding protein 5
CTH cystathionine gamma-lyase
CTSS cathepsin S
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
E2F2 E2F transcription factor 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EHD1 EH-domain containing 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EZR ezrin
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IFT57 intraflagellar transport 57
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITCH itchy E3 ubiquitin protein ligase
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MEG3 maternally expressed 3 (non-protein coding)
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLF1 myeloid leukemia factor 1
MT1F metallothionein 1F
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NRIP1 nuclear receptor interacting protein 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGM3 phosphoglucomutase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RND1 Rho family GTPase 1
RNF19B ring finger protein 19B
RRAD Ras-related associated with diabetes
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC4 syndecan 4
SEC24A SEC24 family member A
SELE selectin E
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK3 SIK family kinase 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPAG9 sperm associated antigen 9
SRGN serglycin
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UBE2H ubiquitin-conjugating enzyme E2H
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
VSIG4 V-set and immunoglobulin domain containing 4
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP1 A kinase (PRKA) anchor protein 1
APOA2 apolipoprotein A-II
B3GNT1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BMP4 bone morphogenetic protein 4
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNA2 cyclin A2
CCND1 cyclin D1
CDC20 cell division cycle 20
CXCL14 chemokine (C-X-C motif) ligand 14
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHRS11 dehydrogenase/reductase (SDR family) member 11
DPYD dihydropyrimidine dehydrogenase
EFCAB14 EF-hand calcium binding domain 14
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
ERLIN2 ER lipid raft associated 2
F2R coagulation factor II (thrombin) receptor
FAM57A family with sequence similarity 57, member A
FZD5 frizzled class receptor 5
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GLIPR1 GLI pathogenesis-related 1
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGB3 high mobility group box 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KANK1 KN motif and ankyrin repeat domains 1
LIN28A lin-28 homolog A (C. elegans)
LY75 lymphocyte antigen 75
MMP12 matrix metallopeptidase 12
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
NUP210 nucleoporin 210kDa
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PODXL podocalyxin-like
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
RAP2A RAP2A, member of RAS oncogene family
RNF43 ring finger protein 43
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SEPHS1 selenophosphate synthetase 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
TYRP1 tyrosinase-related protein 1