BRD-K25737009_-666_HT29_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

419 genes differentially expressed following the BRD-K25737009_-666_HT29_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C3ORF14 chromosome 3 open reading frame 14
C5AR1 complement component 5a receptor 1
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDN3 endothelin 3
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GSTA1 glutathione S-transferase alpha 1
GTF2B general transcription factor IIB
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HECA headcase homolog (Drosophila)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFRD1 interferon-related developmental regulator 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL11 interleukin 11
IL6 interleukin 6
INHBA inhibin, beta A
INHBB inhibin, beta B
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LIN37 lin-37 DREAM MuvB core complex component
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA1 melanoma antigen family A1
MAGEA4 melanoma antigen family A4
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEB nebulin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKX3-1 NK3 homeobox 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
OSBPL1A oxysterol binding protein-like 1A
OSER1 oxidative stress responsive serine-rich 1
PCDH17 protocadherin 17
PCSK5 proprotein convertase subtilisin/kexin type 5
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCDBP protein kinase C, delta binding protein
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RANBP2 RAN binding protein 2
RB1CC1 RB1-inducible coiled-coil 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
RNF19B ring finger protein 19B
RRAD Ras-related associated with diabetes
RSAD2 radical S-adenosyl methionine domain containing 2
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEC63 SEC63 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOBP sine oculis binding protein homolog (Drosophila)
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SOS1 son of sevenless homolog 1 (Drosophila)
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF4 transcription factor 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TWIST1 twist family bHLH transcription factor 1
UPP1 uridine phosphorylase 1
USP18 ubiquitin specific peptidase 18
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZNF165 zinc finger protein 165
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABHD10 abhydrolase domain containing 10
ACSF2 acyl-CoA synthetase family member 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX5 arachidonate 5-lipoxygenase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA7 annexin A7
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASB13 ankyrin repeat and SOCS box containing 13
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BMP4 bone morphogenetic protein 4
BTBD1 BTB (POZ) domain containing 1
C14ORF169 chromosome 14 open reading frame 169
C7 complement component 7
CAPN1 calpain 1, (mu/I) large subunit
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
COG2 component of oligomeric golgi complex 2
COG4 component of oligomeric golgi complex 4
COL3A1 collagen, type III, alpha 1
CTSW cathepsin W
CYBA cytochrome b-245, alpha polypeptide
DALRD3 DALR anticodon binding domain containing 3
DCK deoxycytidine kinase
DDHD2 DDHD domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
EIF4E eukaryotic translation initiation factor 4E
ERBB2 erb-b2 receptor tyrosine kinase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLOT2 flotillin 2
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GCHFR GTP cyclohydrolase I feedback regulator
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLB1 galactosidase, beta 1
GLOD4 glyoxalase domain containing 4
GOLGA8A golgin A8 family, member A
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GZMK granzyme K (granzyme 3; tryptase II)
HADH hydroxyacyl-CoA dehydrogenase
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KAZN kazrin, periplakin interacting protein
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0391 KIAA0391
KIAA0485 uncharacterized LOC57235
KRCC1 lysine-rich coiled-coil 1
LEPR leptin receptor
LOXL1 lysyl oxidase-like 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTA4H leukotriene A4 hydrolase
LY75 lymphocyte antigen 75
LYPLA1 lysophospholipase I
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MRPL12 mitochondrial ribosomal protein L12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTMR1 myotubularin related protein 1
MXRA5 matrix-remodelling associated 5
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBEAL2 neurobeachin-like 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNT nicotinamide nucleotide transhydrogenase
NPM3 nucleophosmin/nucleoplasmin 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSL1 NSL1, MIS12 kinetochore complex component
NUDCD3 NudC domain containing 3
NUP210 nucleoporin 210kDa
OSBPL8 oxysterol binding protein-like 8
PCYOX1L prenylcysteine oxidase 1 like
PDHB pyruvate dehydrogenase (lipoamide) beta
PHB prohibitin
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAT plasminogen activator, tissue
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPA2 pyrophosphatase (inorganic) 2
PPT1 palmitoyl-protein thioesterase 1
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RAB11A RAB11A, member RAS oncogene family
RNF43 ring finger protein 43
RPA1 replication protein A1, 70kDa
RPIA ribose 5-phosphate isomerase A
RPL22 ribosomal protein L22
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCP2 sterol carrier protein 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT11 septin 11
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D16 TBC1 domain family, member 16
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMC5 transmembrane channel-like 5
TMEM168 transmembrane protein 168
TMX1 thioredoxin-related transmembrane protein 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TSTA3 tissue specific transplantation antigen P35B
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC13B unc-13 homolog B (C. elegans)
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR61 WD repeat domain 61
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF185 zinc finger protein 185 (LIM domain)