BRD-K25737009_-666_HCC515_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K25737009_-666_HCC515_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLDN4 claudin 4
CLDN7 claudin 7
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSNK1E casein kinase 1, epsilon
CTBP2 C-terminal binding protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FBP1 fructose-1,6-bisphosphatase 1
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GRB10 growth factor receptor-bound protein 10
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IL6 interleukin 6
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
MAMLD1 mastermind-like domain containing 1
MED8 mediator complex subunit 8
MT1F metallothionein 1F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIT1 nitrilase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM4 PDZ and LIM domain 4
PFDN2 prefoldin subunit 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAP1GAP2 RAP1 GTPase activating protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK2 receptor-interacting serine-threonine kinase 2
SARS seryl-tRNA synthetase
SDC4 syndecan 4
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHB Src homology 2 domain containing adaptor protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA4 annexin A4
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
B3GNT1
C3 complement component 3
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CFI complement factor I
COL4A1 collagen, type IV, alpha 1
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FZD2 frizzled class receptor 2
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIST1H1C histone cluster 1, H1c
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAMB1 laminin, beta 1
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPD1 LY6/PLAUR domain containing 1
MCM3 minichromosome maintenance complex component 3
MCOLN1 mucolipin 1
MUC16 mucin 16, cell surface associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUSAP1 nucleolar and spindle associated protein 1
PALMD palmdelphin
PROS1 protein S (alpha)
PRSS23 protease, serine, 23
RBP1 retinol binding protein 1, cellular
RRM2 ribonucleotide reductase M2
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEPP1 selenoprotein P, plasma, 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SNX10 sorting nexin 10
STMN1 stathmin 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TF transferrin
TFRC transferrin receptor
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12