BRD-K25737009_-666_EFO27_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K25737009_-666_EFO27_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CPE carboxypeptidase E
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM208B family with sequence similarity 208, member B
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GTPBP2 GTP binding protein 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL6R interleukin 6 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
ITCH itchy E3 ubiquitin protein ligase
ITM2C integral membrane protein 2C
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP7 microtubule-associated protein 7
MIR22HG MIR22 host gene
MUC4 mucin 4, cell surface associated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RPP38 ribonuclease P/MRP 38kDa subunit
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATS2L spermatogenesis associated, serine-rich 2-like
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TMEM30B transmembrane protein 30B
TRAF4 TNF receptor-associated factor 4
TRAM1 translocation associated membrane protein 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WAC WW domain containing adaptor with coiled-coil
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
B3GNT1
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CD59 CD59 molecule, complement regulatory protein
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLU clusterin
COL4A2 collagen, type IV, alpha 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST1 cystatin SN
CST4 cystatin S
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FHOD3 formin homology 2 domain containing 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD7 frizzled class receptor 7
GAS2L1 growth arrest-specific 2 like 1
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
HSDL2 hydroxysteroid dehydrogenase like 2
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
MMP12 matrix metallopeptidase 12
NEK2 NIMA-related kinase 2
NFE2L3 nuclear factor, erythroid 2-like 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PLEK pleckstrin
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
RBP1 retinol binding protein 1, cellular
REG3A regenerating islet-derived 3 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SFRP1 secreted frizzled-related protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNX10 sorting nexin 10
SRGN serglycin
SYNM synemin, intermediate filament protein
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
ZNF586 zinc finger protein 586