BRD-K25737009_-666_AGS_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K25737009_-666_AGS_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BCL2L2 BCL2-like 2
BMP4 bone morphogenetic protein 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
ECI1 enoyl-CoA delta isomerase 1
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ETNK1 ethanolamine kinase 1
FOXO3 forkhead box O3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GARS glycyl-tRNA synthetase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPATCH8 G patch domain containing 8
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGLJ3 immunoglobulin lambda joining 3
IRF9 interferon regulatory factor 9
KLF4 Kruppel-like factor 4 (gut)
LIMA1 LIM domain and actin binding 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MT1G metallothionein 1G
MT1X metallothionein 1X
MX1 MX dynamin-like GTPase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLK2 polo-like kinase 2
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RTN1 reticulon 1
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFTPB surfactant protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TARS threonyl-tRNA synthetase
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
AHCY adenosylhomocysteinase
AHNAK2 AHNAK nucleoprotein 2
ANXA4 annexin A4
B3GNT1
BCHE butyrylcholinesterase
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCNF cyclin F
CCNG1 cyclin G1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CXCR4 chemokine (C-X-C motif) receptor 4
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HDAC1 histone deacetylase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LOC100505650 uncharacterized LOC100505650
LPL lipoprotein lipase
MMP7 matrix metallopeptidase 7
MRPL17 mitochondrial ribosomal protein L17
MYCBP MYC binding protein
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
OXTR oxytocin receptor
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PRSS23 protease, serine, 23
RBPMS RNA binding protein with multiple splicing
RPS21 ribosomal protein S21
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SLPI secretory leukocyte peptidase inhibitor
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPG small nuclear ribonucleoprotein polypeptide G
SPON1 spondin 1, extracellular matrix protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TPM4 tropomyosin 4
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
YME1L1 YME1-like 1 ATPase