BRD-K25737009_-666_A549_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K25737009_-666_A549_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
ADGRG1 adhesion G protein-coupled receptor G1
ANKRD10 ankyrin repeat domain 10
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CARKD carbohydrate kinase domain containing
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL9A2 collagen, type IX, alpha 2
CPE carboxypeptidase E
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP1 dual specificity phosphatase 1
DUSP8 dual specificity phosphatase 8
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENGASE endo-beta-N-acetylglucosaminidase
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM46A family with sequence similarity 46, member A
FBP1 fructose-1,6-bisphosphatase 1
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GEM GTP binding protein overexpressed in skeletal muscle
GSDMB gasdermin B
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL6 interleukin 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100505650 uncharacterized LOC100505650
LOC399491
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP1 matrix metallopeptidase 1
MSLN mesothelin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PELI1 pellino E3 ubiquitin protein ligase 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLXNA1 plexin A1
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
RRAD Ras-related associated with diabetes
SCGB1D2 secretoglobin, family 1D, member 2
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOX4 SRY (sex determining region Y)-box 4
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TOP1 topoisomerase (DNA) I
TRIB1 tribbles pseudokinase 1
TRIM36 tripartite motif containing 36
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADD3 adducin 3 (gamma)
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALG6 ALG6, alpha-1,3-glucosyltransferase
AMD1 adenosylmethionine decarboxylase 1
ANXA7 annexin A7
ARF4 ADP-ribosylation factor 4
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
BUB3 BUB3 mitotic checkpoint protein
C6ORF120 chromosome 6 open reading frame 120
CALU calumenin
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA2 cyclin A2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDCA4 cell division cycle associated 4
CHPT1 choline phosphotransferase 1
CIRBP cold inducible RNA binding protein
COX11 COX11 cytochrome c oxidase copper chaperone
CPD carboxypeptidase D
CPNE3 copine III
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
DAZAP2 DAZ associated protein 2
DCK deoxycytidine kinase
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EAPP E2F-associated phosphoprotein
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4E eukaryotic translation initiation factor 4E
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL6 ELOVL fatty acid elongase 6
FASTKD5 FAST kinase domains 5
FBN2 fibrillin 2
FBXO3 F-box protein 3
FECH ferrochelatase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCA grancalcin, EF-hand calcium binding protein
GLTP glycolipid transfer protein
GOLGA7 golgin A7
GRSF1 G-rich RNA sequence binding factor 1
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOXA10 homeobox A10
HOXC6 homeobox C6
HSDL2 hydroxysteroid dehydrogenase like 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IL6ST interleukin 6 signal transducer
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0391 KIAA0391
LAMP2 lysosomal-associated membrane protein 2
LBR lamin B receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LYPLA1 lysophospholipase I
MARCKSL1 MARCKS-like 1
MED21 mediator complex subunit 21
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MPZL1 myelin protein zero-like 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
OSBPL8 oxysterol binding protein-like 8
PDHX pyruvate dehydrogenase complex, component X
PEX3 peroxisomal biogenesis factor 3
PLSCR4 phospholipid scramblase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB11A RAB11A, member RAS oncogene family
RAB2A RAB2A, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP1 retinol binding protein 1, cellular
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REST RE1-silencing transcription factor
RNF14 ring finger protein 14
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SEC23A Sec23 homolog A (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SELT selenoprotein T
SKP1 S-phase kinase-associated protein 1
SORD sorbitol dehydrogenase
SRP72 signal recognition particle 72kDa
SSR1 signal sequence receptor, alpha
STOM stomatin
SUB1 SUB1 homolog (S. cerevisiae)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM168 transmembrane protein 168
TMEM185B transmembrane protein 185B
TMX1 thioredoxin-related transmembrane protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1AIP1 torsin A interacting protein 1
TRAM1 translocation associated membrane protein 1
TRAPPC4 trafficking protein particle complex 4
TSPAN6 tetraspanin 6
TWF1 twinfilin actin binding protein 1
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VAMP3 vesicle-associated membrane protein 3
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
YME1L1 YME1-like 1 ATPase