BRD-K25737009_-666_A375_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K25737009_-666_A375_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCL20 chemokine (C-C motif) ligand 20
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MZB1 marginal zone B and B1 cell-specific protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PYCARD PYD and CARD domain containing
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SHB Src homology 2 domain containing adaptor protein B
TCEAL2 transcription elongation factor A (SII)-like 2
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACAT1 acetyl-CoA acetyltransferase 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BST2 bone marrow stromal cell antigen 2
CALU calumenin
CCNA2 cyclin A2
CCND1 cyclin D1
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CLIC4 chloride intracellular channel 4
CLTC clathrin, heavy chain (Hc)
CPD carboxypeptidase D
CTR9 CTR9, Paf1/RNA polymerase II complex component
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM57A family with sequence similarity 57, member A
FSTL1 follistatin-like 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GGNBP2 gametogenetin binding protein 2
HACD2 3-hydroxyacyl-CoA dehydratase 2
HLTF helicase-like transcription factor
HN1L hematological and neurological expressed 1-like
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM2 interferon induced transmembrane protein 2
KDM5D lysine (K)-specific demethylase 5D
KLC1 kinesin light chain 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
MAP7 microtubule-associated protein 7
MKI67 marker of proliferation Ki-67
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS30 mitochondrial ribosomal protein S30
MTCL1 microtubule crosslinking factor 1
NOTCH2 notch 2
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRSS23 protease, serine, 23
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLK STE20-like kinase
SRP54 signal recognition particle 54kDa
STOM stomatin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TSPAN3 tetraspanin 3
UBE3C ubiquitin protein ligase E3C
VCAN versican