BRD-K25731886_-666_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K25731886_-666_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CAT catalase
CCL19 chemokine (C-C motif) ligand 19
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CLSTN1 calsyntenin 1
COL18A1 collagen, type XVIII, alpha 1
COL6A1 collagen, type VI, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DCT dopachrome tautomerase
DMD dystrophin
EDN1 endothelin 1
EFNB2 ephrin-B2
EGF epidermal growth factor
ETV1 ets variant 1
FKBP11 FK506 binding protein 11, 19 kDa
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GMNN geminin, DNA replication inhibitor
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGD homogentisate 1,2-dioxygenase
HSPA1A heat shock 70kDa protein 1A
IL1R2 interleukin 1 receptor, type II
IL4R interleukin 4 receptor
IL6R interleukin 6 receptor
INSIG1 insulin induced gene 1
KAT6B K(lysine) acetyltransferase 6B
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KYNU kynureninase
LMO4 LIM domain only 4
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRC16A leucine rich repeat containing 16A
LRRN3 leucine rich repeat neuronal 3
LTF lactotransferrin
MBNL2 muscleblind-like splicing regulator 2
MEIS1 Meis homeobox 1
MFSD10 major facilitator superfamily domain containing 10
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NFIB nuclear factor I/B
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PARP1 poly (ADP-ribose) polymerase 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PFN2 profilin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PSD3 pleckstrin and Sec7 domain containing 3
RBM47 RNA binding motif protein 47
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRP1B ribosomal RNA processing 1B
SCARB1 scavenger receptor class B, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLBP stem-loop binding protein
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A46 solute carrier family 25, member 46
SPARCL1 SPARC-like 1 (hevin)
SPEN spen family transcriptional repressor
STAMBP STAM binding protein
STAR steroidogenic acute regulatory protein
SYNE1 spectrin repeat containing, nuclear envelope 1
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
THBS4 thrombospondin 4
TPPP3 tubulin polymerization-promoting protein family member 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP33 ubiquitin specific peptidase 33
WFDC2 WAP four-disulfide core domain 2
WRB tryptophan rich basic protein

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
AHNAK AHNAK nucleoprotein
ANXA1 annexin A1
ATRNL1 attractin-like 1
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
DENND1B DENN/MADD domain containing 1B
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF5 eukaryotic translation initiation factor 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GPX1 glutathione peroxidase 1
GSTT1 glutathione S-transferase theta 1
H2AFY H2A histone family, member Y
HBD hemoglobin, delta
HNMT histamine N-methyltransferase
HOPX HOP homeobox
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
KRT20 keratin 20, type I
LST1 leukocyte specific transcript 1
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NELL2 NEL-like 2 (chicken)
NRIP3 nuclear receptor interacting protein 3
PLIN2 perilipin 2
PRDX2 peroxiredoxin 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A10 S100 calcium binding protein A10
SATB2 SATB homeobox 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUBB2A tubulin, beta 2A class IIa
TYROBP TYRO protein tyrosine kinase binding protein
VAT1 vesicle amine transport 1