BRD-K25340465_OSI-930_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K25340465_OSI-930_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
CCL20 chemokine (C-C motif) ligand 20
CD59 CD59 molecule, complement regulatory protein
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CTH cystathionine gamma-lyase
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
ENO2 enolase 2 (gamma, neuronal)
FBN2 fibrillin 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GRIA2 glutamate receptor, ionotropic, AMPA 2
IGHD immunoglobulin heavy constant delta
ISG20 interferon stimulated exonuclease gene 20kDa
KRT19 keratin 19, type I
LPL lipoprotein lipase
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM2 PDZ and LIM domain 2 (mystique)
PHGDH phosphoglycerate dehydrogenase
PLAT plasminogen activator, tissue
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SST somatostatin
TMEM45A transmembrane protein 45A
TP53 tumor protein p53
WDR61 WD repeat domain 61

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ASPN asporin
CRELD2 cysteine-rich with EGF-like domains 2
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EVI2A ecotropic viral integration site 2A
FERMT2 fermitin family member 2
FNBP1L formin binding protein 1-like
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA1033 KIAA1033
LPAR6 lysophosphatidic acid receptor 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MYH11 myosin, heavy chain 11, smooth muscle
MYO5C myosin VC
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PLN phospholamban
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REEP5 receptor accessory protein 5
RNH1 ribonuclease/angiogenin inhibitor 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC35F2 solute carrier family 35, member F2
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
TBL1X transducin (beta)-like 1X-linked
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A