BRD-K25340465_OSI-930_MCF7_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K25340465_OSI-930_MCF7_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKAP8L A kinase (PRKA) anchor protein 8-like
ANXA1 annexin A1
ANXA2 annexin A2
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE41 basic helix-loop-helix family, member e41
CCND1 cyclin D1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DST dystonin
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EBP emopamil binding protein (sterol isomerase)
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV2-23 immunoglobulin lambda variable 2-23
IRF4 interferon regulatory factor 4
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITM2C integral membrane protein 2C
KLHL21 kelch-like family member 21
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LGALS3 lectin, galactoside-binding, soluble, 3
MME membrane metallo-endopeptidase
OSBPL1A oxysterol binding protein-like 1A
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFRL platelet-derived growth factor receptor-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
POU2AF1 POU class 2 associating factor 1
PTN pleiotrophin
RPS5 ribosomal protein S5
S100P S100 calcium binding protein P
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATS2L spermatogenesis associated, serine-rich 2-like
SYNM synemin, intermediate filament protein
TFF1 trefoil factor 1
TRIM29 tripartite motif containing 29
VIM vimentin
XPO7 exportin 7
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ASCL1 achaete-scute family bHLH transcription factor 1
BCHE butyrylcholinesterase
C4BPA complement component 4 binding protein, alpha
COG4 component of oligomeric golgi complex 4
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DYNLT1 dynein, light chain, Tctex-type 1
EIF5A eukaryotic translation initiation factor 5A
FBXL12 F-box and leucine-rich repeat protein 12
GATA3 GATA binding protein 3
HSPA1A heat shock 70kDa protein 1A
IRF8 interferon regulatory factor 8
LGALS2 lectin, galactoside-binding, soluble, 2
LYZ lysozyme
MARCKSL1 MARCKS-like 1
MPZL2 myelin protein zero-like 2
MT1M metallothionein 1M
MYO6 myosin VI
NREP neuronal regeneration related protein
OXSR1 oxidative stress responsive 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHACTR2 phosphatase and actin regulator 2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
REEP1 receptor accessory protein 1
TBX3 T-box 3
TCEAL4 transcription elongation factor A (SII)-like 4