BRD-K25340465_OSI-930_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K25340465_OSI-930_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ARG1 arginase 1
ASPN asporin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD1C CD1c molecule
CD24 CD24 molecule
CREB1 cAMP responsive element binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EXOSC4 exosome component 4
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GC group-specific component (vitamin D binding protein)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
KIAA1598
L1CAM L1 cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
OLFML2A olfactomedin-like 2A
PAH phenylalanine hydroxylase
PBLD phenazine biosynthesis-like protein domain containing
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PHGDH phosphoglycerate dehydrogenase
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
VAT1 vesicle amine transport 1
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C1QB complement component 1, q subcomponent, B chain
CCND2 cyclin D2
CD3D CD3d molecule, delta (CD3-TCR complex)
CD69 CD69 molecule
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
FABP7 fatty acid binding protein 7, brain
FGF13 fibroblast growth factor 13
GUSBP11 glucuronidase, beta pseudogene 11
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
ITM2C integral membrane protein 2C
KIF20A kinesin family member 20A
MCAM melanoma cell adhesion molecule
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MZB1 marginal zone B and B1 cell-specific protein
NBL1 neuroblastoma 1, DAN family BMP antagonist
NPEPL1 aminopeptidase-like 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
P3H2 prolyl 3-hydroxylase 2
PAM peptidylglycine alpha-amidating monooxygenase
PDE4D phosphodiesterase 4D, cAMP-specific
PGAM1 phosphoglycerate mutase 1 (brain)
PLK2 polo-like kinase 2
PODXL podocalyxin-like
PSRC1 proline/serine-rich coiled-coil 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
STK17A serine/threonine kinase 17a
STK26 serine/threonine protein kinase 26
TMEM47 transmembrane protein 47