BRD-K25340465_OSI-930_HEPG2_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K25340465_OSI-930_HEPG2_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
BASP1 brain abundant, membrane attached signal protein 1
BCL2 B-cell CLL/lymphoma 2
BHLHE41 basic helix-loop-helix family, member e41
C8ORF4 chromosome 8 open reading frame 4
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
DRAM1 DNA-damage regulated autophagy modulator 1
EGR1 early growth response 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPCAM epithelial cell adhesion molecule
FZD7 frizzled class receptor 7
GLCE glucuronic acid epimerase
HOXA10 homeobox A10
KCTD12 potassium channel tetramerization domain containing 12
LTBP3 latent transforming growth factor beta binding protein 3
NRP1 neuropilin 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PTHLH parathyroid hormone-like hormone
RBMS1 RNA binding motif, single stranded interacting protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
USP6NL USP6 N-terminal like
VIM vimentin
VNN1 vanin 1

decreased expression

Symbol Name
AEBP1 AE binding protein 1
ALB albumin
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
C1QA complement component 1, q subcomponent, A chain
CDC20 cell division cycle 20
COL9A2 collagen, type IX, alpha 2
CTSV cathepsin V
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
ISLR immunoglobulin superfamily containing leucine-rich repeat
LDLR low density lipoprotein receptor
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PEG3 paternally expressed 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPIA ribose 5-phosphate isomerase A
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SQLE squalene epoxidase
TES testin LIM domain protein
TF transferrin
TTN titin
TTR transthyretin