BRD-K25340465_OSI-930_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K25340465_OSI-930_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABLIM1 actin binding LIM protein 1
AGR2 anterior gradient 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
CTSB cathepsin B
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GDF15 growth differentiation factor 15
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
MAPT microtubule-associated protein tau
MLPH melanophilin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTUS1 microtubule associated tumor suppressor 1
NEBL nebulette
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PHGDH phosphoglycerate dehydrogenase
PYCR1 pyrroline-5-carboxylate reductase 1
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
TARS threonyl-tRNA synthetase
TGM2 transglutaminase 2
TP53 tumor protein p53

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA2 annexin A2
C1S complement component 1, s subcomponent
CCL2 chemokine (C-C motif) ligand 2
CDC25B cell division cycle 25B
CDH3 cadherin 3, type 1, P-cadherin (placental)
COL15A1 collagen, type XV, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
GJA1 gap junction protein, alpha 1, 43kDa
HK1 hexokinase 1
IFI27 interferon, alpha-inducible protein 27
KCTD12 potassium channel tetramerization domain containing 12
KIF2C kinesin family member 2C
KRT13 keratin 13, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
MARCKS myristoylated alanine-rich protein kinase C substrate
PKM pyruvate kinase, muscle
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
XIST X inactive specific transcript (non-protein coding)