BRD-K25340465_OSI-930_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K25340465_OSI-930_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
CA12 carbonic anhydrase XII
CCNE2 cyclin E2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DEFA5 defensin, alpha 5, Paneth cell-specific
EVI2A ecotropic viral integration site 2A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FJX1 four jointed box 1 (Drosophila)
GLRX glutaredoxin (thioltransferase)
HMGA2 high mobility group AT-hook 2
HPCAL1 hippocalcin-like 1
ITGA6 integrin, alpha 6
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAZN kazrin, periplakin interacting protein
KRAS Kirsten rat sarcoma viral oncogene homolog
LAPTM4B lysosomal protein transmembrane 4 beta
MRPS2 mitochondrial ribosomal protein S2
MSLN mesothelin
MUC5B mucin 5B, oligomeric mucus/gel-forming
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFE2L2 nuclear factor, erythroid 2-like 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PRR15L proline rich 15-like
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SRGN serglycin
TOR4A torsin family 4, member A
TSPAN5 tetraspanin 5
XPO7 exportin 7
ZNF185 zinc finger protein 185 (LIM domain)
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DHCR7 7-dehydrocholesterol reductase
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
ELN elastin
EPAS1 endothelial PAS domain protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FILIP1L filamin A interacting protein 1-like
G0S2 G0/G1 switch 2
GLUL glutamate-ammonia ligase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
INSR insulin receptor
IPO13 importin 13
ITM2A integral membrane protein 2A
LUM lumican
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MXRA5 matrix-remodelling associated 5
MYH11 myosin, heavy chain 11, smooth muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
PALLD palladin, cytoskeletal associated protein
PBX3 pre-B-cell leukemia homeobox 3
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PICALM phosphatidylinositol binding clathrin assembly protein
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRELP proline/arginine-rich end leucine-rich repeat protein
RGS5 regulator of G-protein signaling 5
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNX7 sorting nexin 7
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SULF1 sulfatase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZIC1 Zic family member 1
ZNF589 zinc finger protein 589