BRD-K25340465_OSI-930_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K25340465_OSI-930_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
C14ORF132 chromosome 14 open reading frame 132
C8ORF4 chromosome 8 open reading frame 4
CAPG capping protein (actin filament), gelsolin-like
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CFD complement factor D (adipsin)
CPD carboxypeptidase D
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IGFBP6 insulin-like growth factor binding protein 6
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KAT6B K(lysine) acetyltransferase 6B
KIAA0753 KIAA0753
MAN1A1 mannosidase, alpha, class 1A, member 1
MAST4 microtubule associated serine/threonine kinase family member 4
MDK midkine (neurite growth-promoting factor 2)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
PYCR1 pyrroline-5-carboxylate reductase 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TFPI2 tissue factor pathway inhibitor 2
TM9SF3 transmembrane 9 superfamily member 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TST thiosulfate sulfurtransferase (rhodanese)
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ATG3 autophagy related 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BPHL biphenyl hydrolase-like (serine hydrolase)
C3ORF52 chromosome 3 open reading frame 52
CCDC86 coiled-coil domain containing 86
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXADR coxsackie virus and adenovirus receptor
DSP desmoplakin
EZR ezrin
F2R coagulation factor II (thrombin) receptor
FOXJ3 forkhead box J3
GCH1 GTP cyclohydrolase 1
HOXB7 homeobox B7
IDI1 isopentenyl-diphosphate delta isomerase 1
IQGAP1 IQ motif containing GTPase activating protein 1
KRT17 keratin 17, type I
LAMP5 lysosomal-associated membrane protein family, member 5
MLF1 myeloid leukemia factor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PDHB pyruvate dehydrogenase (lipoamide) beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
S100B S100 calcium binding protein B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TMEM2 transmembrane protein 2
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TWF1 twinfilin actin binding protein 1
WDR7 WD repeat domain 7
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta