BRD-K24515980_QL-XI-92_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K24515980_QL-XI-92_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMDHD2 amidohydrolase domain containing 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BAG2 BCL2-associated athanogene 2
CBR1 carbonyl reductase 1
CCDC92 coiled-coil domain containing 92
CD53 CD53 molecule
CES1 carboxylesterase 1
CPVL carboxypeptidase, vitellogenic-like
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
FAM134B family with sequence similarity 134, member B
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGG fibrinogen gamma chain
FOSL2 FOS-like antigen 2
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT18 keratin 18, type I
LAPTM5 lysosomal protein transmembrane 5
LIPA lipase A, lysosomal acid, cholesterol esterase
LY96 lymphocyte antigen 96
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
NEFL neurofilament, light polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSPH phosphoserine phosphatase
RBKS ribokinase
RUNX1 runt-related transcription factor 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SIRT3 sirtuin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GAS7 growth arrest-specific 7
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB6 homeobox B6
HOXB7 homeobox B7
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
KLF4 Kruppel-like factor 4 (gut)
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRC1 protein regulator of cytokinesis 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RFC3 replication factor C (activator 1) 3, 38kDa
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SCEL sciellin
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPPP3 tubulin polymerization-promoting protein family member 3
TPX2 TPX2, microtubule-associated
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPK1B uroplakin 1B
VIM vimentin
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1