BRD-K24515980_QL-XI-92_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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82 genes differentially expressed following the BRD-K24515980_QL-XI-92_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C2CD5 C2 calcium-dependent domain containing 5
CASP1 caspase 1, apoptosis-related cysteine peptidase
CFI complement factor I
CTSS cathepsin S
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
HMGA2 high mobility group AT-hook 2
IFRD2 interferon-related developmental regulator 2
JADE2 jade family PHD finger 2
LAPTM4B lysosomal protein transmembrane 4 beta
LYPLA1 lysophospholipase I
MAN1C1 mannosidase, alpha, class 1C, member 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMD monocyte to macrophage differentiation-associated
NELL2 NEL-like 2 (chicken)
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX1A syntaxin 1A (brain)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
VCAN versican
XPO7 exportin 7

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AREG amphiregulin
ASS1 argininosuccinate synthase 1
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CHMP4A charged multivesicular body protein 4A
CLU clusterin
CNN3 calponin 3, acidic
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CST6 cystatin E/M
CYB5A cytochrome b5 type A (microsomal)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSN gelsolin
HBB hemoglobin, beta
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
JUNB jun B proto-oncogene
KLK6 kallikrein-related peptidase 6
LAMP3 lysosomal-associated membrane protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
MAN1A1 mannosidase, alpha, class 1A, member 1
MGP matrix Gla protein
MPC1 mitochondrial pyruvate carrier 1
MTSS1 metastasis suppressor 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P3H2 prolyl 3-hydroxylase 2
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLSCR3 phospholipid scramblase 3
PLXND1 plexin D1
PRPF4 pre-mRNA processing factor 4
PTN pleiotrophin
RCAN1 regulator of calcineurin 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELE selectin E
SGCE sarcoglycan, epsilon
SULF1 sulfatase 1
THSD7A thrombospondin, type I, domain containing 7A
TMEM100 transmembrane protein 100