BRD-K24496482_SB590885_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K24496482_SB590885_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BACE2 beta-site APP-cleaving enzyme 2
BLVRB biliverdin reductase B
C5 complement component 5
CD44 CD44 molecule (Indian blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CLCA2 chloride channel accessory 2
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGHD immunoglobulin heavy constant delta
ITGB1BP1 integrin beta 1 binding protein 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT15 keratin 15, type I
KYNU kynureninase
LTF lactotransferrin
LYST lysosomal trafficking regulator
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MEGF9 multiple EGF-like-domains 9
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MYO10 myosin X
NCAM1 neural cell adhesion molecule 1
NMRK1 nicotinamide riboside kinase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPN3 opsin 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PYCARD PYD and CARD domain containing
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SETBP1 SET binding protein 1
SFRP1 secreted frizzled-related protein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR7 WD repeat domain 7
WNT5A wingless-type MMTV integration site family, member 5A
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDOA aldolase A, fructose-bisphosphate
ANXA5 annexin A5
AREG amphiregulin
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CALD1 caldesmon 1
CLU clusterin
COMP cartilage oligomeric matrix protein
CRCT1 cysteine-rich C-terminal 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EBNA1BP2 EBNA1 binding protein 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAT1 FAT atypical cadherin 1
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
JAG1 jagged 1
LUM lumican
NNMT nicotinamide N-methyltransferase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PENK proenkephalin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PUS7 pseudouridylate synthase 7 (putative)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SPARCL1 SPARC-like 1 (hevin)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN4 tetraspanin 4
UBE2S ubiquitin-conjugating enzyme E2S