BRD-K24132293_piperlongumine (HPLC)_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K24132293_piperlongumine (HPLC)_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CD163 CD163 molecule
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CLIC4 chloride intracellular channel 4
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTH cystathionine gamma-lyase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GATA6 GATA binding protein 6
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IQGAP1 IQ motif containing GTPase activating protein 1
JCHAIN joining chain of multimeric IgA and IgM
JUNB jun B proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LEFTY1 left-right determination factor 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1M metallothionein 1M
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PKP2 plakophilin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRRC2C proline-rich coiled-coil 2C
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC3 serine incorporator 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SNX7 sorting nexin 7
SQSTM1 sequestosome 1
STAR steroidogenic acute regulatory protein
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TTC3 tetratricopeptide repeat domain 3
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UGDH UDP-glucose 6-dehydrogenase
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UPP1 uridine phosphorylase 1
VSIG4 V-set and immunoglobulin domain containing 4
WASL Wiskott-Aldrich syndrome-like
ZFP36 ZFP36 ring finger protein
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CENPA centromere protein A
CTSC cathepsin C
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DUOX2 dual oxidase 2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENO2 enolase 2 (gamma, neuronal)
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
F5 coagulation factor V (proaccelerin, labile factor)
FAM216A family with sequence similarity 216, member A
GPC3 glypican 3
GTF2H5 general transcription factor IIH, polypeptide 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KANK1 KN motif and ankyrin repeat domains 1
KIAA0391 KIAA0391
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
NME4 NME/NM23 nucleoside diphosphate kinase 4
OXA1L oxidase (cytochrome c) assembly 1-like
PDGFA platelet-derived growth factor alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PGM1 phosphoglucomutase 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSCA prostate stem cell antigen
SDPR serum deprivation response
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP2 tight junction protein 2
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM185B transmembrane protein 185B
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPYL5 TSPY-like 5
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBL3 ubiquitin-like 3
UPK1B uroplakin 1B