BRD-K23984367_sorafenib_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K23984367_sorafenib_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ANO1 anoctamin 1, calcium activated chloride channel
ARG1 arginase 1
ASCL1 achaete-scute family bHLH transcription factor 1
BCL2A1 BCL2-related protein A1
BRCA1 breast cancer 1, early onset
BTK Bruton agammaglobulinemia tyrosine kinase
C7 complement component 7
CA12 carbonic anhydrase XII
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CLU clusterin
COL11A1 collagen, type XI, alpha 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERAP2 endoplasmic reticulum aminopeptidase 2
FHL1 four and a half LIM domains 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GHR growth hormone receptor
GMDS GDP-mannose 4,6-dehydratase
GZMK granzyme K (granzyme 3; tryptase II)
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNRNPL heterogeneous nuclear ribonucleoprotein L
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRF4 interferon regulatory factor 4
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KIAA1324 KIAA1324
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KYNU kynureninase
LRMP lymphoid-restricted membrane protein
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
LY75 lymphocyte antigen 75
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MTCL1 microtubule crosslinking factor 1
NKG7 natural killer cell granule protein 7
NRN1 neuritin 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAX5 paired box 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLAC8 placenta-specific 8
PLEK pleckstrin
PRF1 perforin 1 (pore forming protein)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RCAN1 regulator of calcineurin 1
RUNX3 runt-related transcription factor 3
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SORBS1 sorbin and SH3 domain containing 1
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
TATDN2 TatD DNase domain containing 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
APP amyloid beta (A4) precursor protein
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
CAST calpastatin
CLIC5 chloride intracellular channel 5
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXADR coxsackie virus and adenovirus receptor
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHCR24 24-dehydrocholesterol reductase
DOCK4 dedicator of cytokinesis 4
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
FBXO21 F-box protein 21
FN1 fibronectin 1
FRMD4B FERM domain containing 4B
GOLT1B golgi transport 1B
GTPBP8 GTP-binding protein 8 (putative)
HIST1H4C histone cluster 1, H4c
HIST3H2A histone cluster 3, H2a
ITFG1 integrin alpha FG-GAP repeat containing 1
JUND jun D proto-oncogene
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MRPS16 mitochondrial ribosomal protein S16
MSLN mesothelin
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PTRF polymerase I and transcript release factor
RAB38 RAB38, member RAS oncogene family
RGCC regulator of cell cycle
SASH1 SAM and SH3 domain containing 1
SEPT10 septin 10
SGK1 serum/glucocorticoid regulated kinase 1
SMC1A structural maintenance of chromosomes 1A
TM4SF1 transmembrane 4 L six family member 1
TRIM29 tripartite motif containing 29
TULP3 tubby like protein 3
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF331 zinc finger protein 331