BRD-K23984367_sorafenib_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K23984367_sorafenib_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BANK1 B-cell scaffold protein with ankyrin repeats 1
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CCP110 centriolar coiled coil protein 110kDa
CD24 CD24 molecule
CLIC3 chloride intracellular channel 3
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
F8 coagulation factor VIII, procoagulant component
G0S2 G0/G1 switch 2
GRAMD3 GRAM domain containing 3
HIST1H2BG histone cluster 1, H2bg
ICAM1 intercellular adhesion molecule 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
KLF4 Kruppel-like factor 4 (gut)
LIF leukemia inhibitory factor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NPR3 natriuretic peptide receptor 3
PLA2G16 phospholipase A2, group XVI
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
TFF3 trefoil factor 3 (intestinal)
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXNIP thioredoxin interacting protein
VLDLR very low density lipoprotein receptor
ZMAT3 zinc finger, matrin-type 3
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACOT9 acyl-CoA thioesterase 9
AK4 adenylate kinase 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CANT1 calcium activated nucleotidase 1
CBFB core-binding factor, beta subunit
CCDC109B coiled-coil domain containing 109B
CCNB2 cyclin B2
CCND2 cyclin D2
CD99 CD99 molecule
CPB1 carboxypeptidase B1 (tissue)
DLK1 delta-like 1 homolog (Drosophila)
DST dystonin
EFNA1 ephrin-A1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERBB2 erb-b2 receptor tyrosine kinase 2
FGFR1 fibroblast growth factor receptor 1
FNBP1 formin binding protein 1
GJA1 gap junction protein, alpha 1, 43kDa
H2AFV H2A histone family, member V
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KDM3A lysine (K)-specific demethylase 3A
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
LIMA1 LIM domain and actin binding 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MTERF3 mitochondrial transcription termination factor 3
MTUS1 microtubule associated tumor suppressor 1
MXRA7 matrix-remodelling associated 7
MYH10 myosin, heavy chain 10, non-muscle
NFIB nuclear factor I/B
PDGFA platelet-derived growth factor alpha polypeptide
PLIN2 perilipin 2
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
SPON2 spondin 2, extracellular matrix protein
SUB1 SUB1 homolog (S. cerevisiae)
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TUBB2A tubulin, beta 2A class IIa