BRD-K23984367_sorafenib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K23984367_sorafenib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1C2 aldo-keto reductase family 1, member C2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUTS2 autism susceptibility candidate 2
BLVRB biliverdin reductase B
BPGM 2,3-bisphosphoglycerate mutase
C14ORF132 chromosome 14 open reading frame 132
CAPG capping protein (actin filament), gelsolin-like
CBR3 carbonyl reductase 3
CD14 CD14 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L2 chitinase 3-like 2
CKB creatine kinase, brain
CNOT4 CCR4-NOT transcription complex, subunit 4
CNPY3 canopy FGF signaling regulator 3
CSTA cystatin A (stefin A)
DACH1 dachshund family transcription factor 1
DHCR7 7-dehydrocholesterol reductase
DST dystonin
DSTN destrin (actin depolymerizing factor)
EPHB2 EPH receptor B2
FCGBP Fc fragment of IgG binding protein
FOXG1 forkhead box G1
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
LEFTY1 left-right determination factor 1
NAMPT nicotinamide phosphoribosyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEBL nebulette
OLFM4 olfactomedin 4
PGD phosphogluconate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
RAB40B RAB40B, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SH3YL1 SH3 and SYLF domain containing 1
SIRT3 sirtuin 3
SNCAIP synuclein, alpha interacting protein
SORD sorbitol dehydrogenase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TCAF1 TRPM8 channel-associated factor 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
AHR aryl hydrocarbon receptor
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
BACE2 beta-site APP-cleaving enzyme 2
BTG3 BTG family, member 3
CLEC11A C-type lectin domain family 11, member A
CLGN calmegin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DUSP6 dual specificity phosphatase 6
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FGF13 fibroblast growth factor 13
FST follistatin
GOLGA8A golgin A8 family, member A
HDAC9 histone deacetylase 9
HOXB2 homeobox B2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
ITM2A integral membrane protein 2A
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LMCD1 LIM and cysteine-rich domains 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NT5E 5'-nucleotidase, ecto (CD73)
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRSS21 protease, serine, 21 (testisin)
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCE sarcoglycan, epsilon
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
VIM vimentin
ZBED2 zinc finger, BED-type containing 2