BRD-K23875128_Rho kinase inhibitor III [rockout]_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF62 chromosome 6 open reading frame 62
CD24 CD24 molecule
CLDN10 claudin 10
CST6 cystatin E/M
DSP desmoplakin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT17 keratin 17, type I
LPCAT1 lysophosphatidylcholine acyltransferase 1
MMD monocyte to macrophage differentiation-associated
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
RAI14 retinoic acid induced 14
RBPMS RNA binding protein with multiple splicing
RNF167 ring finger protein 167
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SMC3 structural maintenance of chromosomes 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TOX3 TOX high mobility group box family member 3
TRIB1 tribbles pseudokinase 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB2B tubulin, beta 2B class IIb
UBE3C ubiquitin protein ligase E3C
UFM1 ubiquitin-fold modifier 1
USP22 ubiquitin specific peptidase 22
VCAM1 vascular cell adhesion molecule 1
VLDLR very low density lipoprotein receptor
ZNF264 zinc finger protein 264
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CES1 carboxylesterase 1
CTGF connective tissue growth factor
GPX3 glutathione peroxidase 3
HEBP2 heme binding protein 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R2 interleukin 1 receptor, type II
LGALS1 lectin, galactoside-binding, soluble, 1
MAOA monoamine oxidase A
MGP matrix Gla protein
PLAC8 placenta-specific 8
PRAME preferentially expressed antigen in melanoma
PTX3 pentraxin 3, long
RGS5 regulator of G-protein signaling 5
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TF transferrin
TM4SF1 transmembrane 4 L six family member 1
VWF von Willebrand factor