BRD-K23875128_Rho kinase inhibitor III [rockout]_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
AREG amphiregulin
C5AR1 complement component 5a receptor 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CYBB cytochrome b-245, beta polypeptide
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSTM3 glutathione S-transferase mu 3 (brain)
HMGA2 high mobility group AT-hook 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
KCTD14 potassium channel tetramerization domain containing 14
KIF1A kinesin family member 1A
KRT14 keratin 14, type I
MLXIP MLX interacting protein
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
PECAM1 platelet/endothelial cell adhesion molecule 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PTPRE protein tyrosine phosphatase, receptor type, E
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A14 S100 calcium binding protein A14
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TSC22D3 TSC22 domain family, member 3
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATF3 activating transcription factor 3
BAG2 BCL2-associated athanogene 2
BLNK B-cell linker
BPHL biphenyl hydrolase-like (serine hydrolase)
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLDN4 claudin 4
CLIC4 chloride intracellular channel 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FGF13 fibroblast growth factor 13
FNBP1 formin binding protein 1
FSD1 fibronectin type III and SPRY domain containing 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAS GNAS complex locus
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF20A kinesin family member 20A
LMO4 LIM domain only 4
LRMP lymphoid-restricted membrane protein
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKX3-1 NK3 homeobox 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RFC2 replication factor C (activator 1) 2, 40kDa
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TCF4 transcription factor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10