BRD-K23875128_Rho kinase inhibitor III [rockout]_OV7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOD apolipoprotein D
AREG amphiregulin
ATM ATM serine/threonine kinase
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL8A1 collagen, type VIII, alpha 1
CPD carboxypeptidase D
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
EFNB2 ephrin-B2
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FKBP5 FK506 binding protein 5
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GZMK granzyme K (granzyme 3; tryptase II)
HOPX HOP homeobox
HOXC6 homeobox C6
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
KRT7 keratin 7, type II
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER1 period circadian clock 1
PRKCH protein kinase C, eta
SLC38A2 solute carrier family 38, member 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TSC22D3 TSC22 domain family, member 3
ZBTB16 zinc finger and BTB domain containing 16
ZNF266 zinc finger protein 266
ZNF544 zinc finger protein 544
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A1CF APOBEC1 complementation factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALB albumin
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL15A1 collagen, type XV, alpha 1
CRP C-reactive protein, pentraxin-related
CXCL8 chemokine (C-X-C motif) ligand 8
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUOX2 dual oxidase 2
EGFR epidermal growth factor receptor
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX2 glutathione peroxidase 2
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
ISOC1 isochorismatase domain containing 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JUN jun proto-oncogene
KIF5B kinesin family member 5B
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR6 lysophosphatidic acid receptor 6
MTSS1 metastasis suppressor 1
NME5 NME/NM23 family member 5
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLAUR plasminogen activator, urokinase receptor
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REG1A regenerating islet-derived 1 alpha
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAA4 serum amyloid A4, constitutive
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VWA5A von Willebrand factor A domain containing 5A
WNT5A wingless-type MMTV integration site family, member 5A