BRD-K23875128_Rho kinase inhibitor III [rockout]_NCIH2073_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADRB2 adrenoceptor beta 2, surface
AEBP1 AE binding protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP13 A kinase (PRKA) anchor protein 13
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASRGL1 asparaginase like 1
BCL6 B-cell CLL/lymphoma 6
C3 complement component 3
CA12 carbonic anhydrase XII
CAV2 caveolin 2
CFH complement factor H
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDIT4 DNA-damage-inducible transcript 4
EMP1 epithelial membrane protein 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FBXO11 F-box protein 11
FGF9 fibroblast growth factor 9
FKBP5 FK506 binding protein 5
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GRB14 growth factor receptor-bound protein 14
HAL histidine ammonia-lyase
HOMER2 homer scaffolding protein 2
HOXC6 homeobox C6
IL1R2 interleukin 1 receptor, type II
KIAA0040 KIAA0040
KLF9 Kruppel-like factor 9
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MBNL1 muscleblind-like splicing regulator 1
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MSMB microseminoprotein, beta-
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1M metallothionein 1M
MT1X metallothionein 1X
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
PDLIM1 PDZ and LIM domain 1
PDZK1 PDZ domain containing 1
PER1 period circadian clock 1
PI3 peptidase inhibitor 3, skin-derived
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLA Src-like-adaptor
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC46A3 solute carrier family 46, member 3
SLPI secretory leukocyte peptidase inhibitor
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM176B transmembrane protein 176B
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VCAN versican
VGLL1 vestigial-like family member 1
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADI1 acireductone dioxygenase 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
BAMBI BMP and activin membrane-bound inhibitor
BCL2A1 BCL2-related protein A1
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CALML5 calmodulin-like 5
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL6A3 collagen, type VI, alpha 3
COL9A2 collagen, type IX, alpha 2
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEGS1 delta(4)-desaturase, sphingolipid 1
DOCK10 dedicator of cytokinesis 10
DUSP4 dual specificity phosphatase 4
EFHD2 EF-hand domain family, member D2
EFS embryonal Fyn-associated substrate
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GCH1 GTP cyclohydrolase 1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
GRK5 G protein-coupled receptor kinase 5
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LIMCH1 LIM and calponin homology domains 1
LYPD1 LY6/PLAUR domain containing 1
MAPK13 mitogen-activated protein kinase 13
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MMP12 matrix metallopeptidase 12
MYO10 myosin X
NFE2L3 nuclear factor, erythroid 2-like 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NVL nuclear VCP-like
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLXNC1 plexin C1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF43 ring finger protein 43
SCGB1D2 secretoglobin, family 1D, member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SSFA2 sperm specific antigen 2
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
VTCN1 V-set domain containing T cell activation inhibitor 1