BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AEBP1 AE binding protein 1
AIM1 absent in melanoma 1
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CDC42 cell division cycle 42
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN3 claudin 3
CLDN7 claudin 7
COL11A1 collagen, type XI, alpha 1
CSTA cystatin A (stefin A)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
FKBP5 FK506 binding protein 5
FOXN3 forkhead box N3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KLF6 Kruppel-like factor 6
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
MAOA monoamine oxidase A
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MYO1B myosin IB
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
OSR2 odd-skipped related transciption factor 2
PER1 period circadian clock 1
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PRKCD protein kinase C, delta
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SIK1 salt-inducible kinase 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HOMER1 homer scaffolding protein 1
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KDM3A lysine (K)-specific demethylase 3A
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LMO4 LIM domain only 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
NAV3 neuron navigator 3
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PRNP prion protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGL1 ral guanine nucleotide dissociation stimulator-like 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMAD3 SMAD family member 3
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)