BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CDV3 CDV3 homolog (mouse)
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
COL11A1 collagen, type XI, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTSD cathepsin D
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP1 dual specificity phosphatase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FGG fibrinogen gamma chain
FKBP5 FK506 binding protein 5
GLS glutaminase
GLUL glutamate-ammonia ligase
KLF9 Kruppel-like factor 9
MAOA monoamine oxidase A
MSLN mesothelin
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PEG10 paternally expressed 10
PER1 period circadian clock 1
PRR15L proline rich 15-like
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
TMEM243 transmembrane protein 243, mitochondrial
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARD10 caspase recruitment domain family, member 10
CCL2 chemokine (C-C motif) ligand 2
CDO1 cysteine dioxygenase type 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNM1 dynamin 1
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFS embryonal Fyn-associated substrate
EPHB2 EPH receptor B2
ETV5 ets variant 5
FADS1 fatty acid desaturase 1
FANCL Fanconi anemia, complementation group L
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
KLK11 kallikrein-related peptidase 11
LGALS1 lectin, galactoside-binding, soluble, 1
LIMA1 LIM domain and actin binding 1
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MGLL monoglyceride lipase
MID1 midline 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NKX3-1 NK3 homeobox 1
NRP1 neuropilin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
PALLD palladin, cytoskeletal associated protein
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAP1GAP RAP1 GTPase activating protein
RHOBTB3 Rho-related BTB domain containing 3
RHOC ras homolog family member C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SCG5 secretogranin V
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SOX2 SRY (sex determining region Y)-box 2
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SYNJ2 synaptojanin 2
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TSPAN5 tetraspanin 5
TUBB2A tubulin, beta 2A class IIa
UBE2S ubiquitin-conjugating enzyme E2S
UGDH UDP-glucose 6-dehydrogenase
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC24 zinc finger, CCHC domain containing 24