BRD-K23875128_Rho kinase inhibitor III [rockout]_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
BPHL biphenyl hydrolase-like (serine hydrolase)
BPIFA1 BPI fold containing family A, member 1
C10ORF10 chromosome 10 open reading frame 10
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FKBP5 FK506 binding protein 5
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
KDM5D lysine (K)-specific demethylase 5D
LAMP3 lysosomal-associated membrane protein 3
LIMCH1 LIM and calponin homology domains 1
NEFL neurofilament, light polypeptide
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ANXA3 annexin A3
C3ORF14 chromosome 3 open reading frame 14
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CLIC3 chloride intracellular channel 3
COL6A2 collagen, type VI, alpha 2
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
G0S2 G0/G1 switch 2
GAS1 growth arrest-specific 1
GLIPR1 GLI pathogenesis-related 1
HEPH hephaestin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
LCN2 lipocalin 2
LXN latexin
MARCKSL1 MARCKS-like 1
MOK MOK protein kinase
MXRA7 matrix-remodelling associated 7
NET1 neuroepithelial cell transforming 1
OLFM4 olfactomedin 4
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
QPCT glutaminyl-peptide cyclotransferase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RHOBTB3 Rho-related BTB domain containing 3
SORD sorbitol dehydrogenase
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TPBG trophoblast glycoprotein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XIST X inactive specific transcript (non-protein coding)
ZMIZ1 zinc finger, MIZ-type containing 1