BRD-K23875128_Rho kinase inhibitor III [rockout]_H1299_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
C1ORF174 chromosome 1 open reading frame 174
CALR calreticulin
CAV1 caveolin 1, caveolae protein, 22kDa
CD9 CD9 molecule
CEP104 centrosomal protein 104kDa
CLCA1 chloride channel accessory 1
CLCA4 chloride channel accessory 4
CLDN3 claudin 3
CLDN7 claudin 7
COMP cartilage oligomeric matrix protein
CREG1 cellular repressor of E1A-stimulated genes 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FAM3C family with sequence similarity 3, member C
FN1 fibronectin 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GREM1 gremlin 1, DAN family BMP antagonist
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LBH limb bud and heart development
LOX lysyl oxidase
LRRC15 leucine rich repeat containing 15
MTUS1 microtubule associated tumor suppressor 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRN1 neuritin 1
PRDX1 peroxiredoxin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC35F2 solute carrier family 35, member F2
SPINK1 serine peptidase inhibitor, Kazal type 1
SRI sorcin
SYNJ2 synaptojanin 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
ADD3 adducin 3 (gamma)
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANGPT1 angiopoietin 1
ANXA6 annexin A6
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
C1ORF106 chromosome 1 open reading frame 106
CALML5 calmodulin-like 5
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC86 coiled-coil domain containing 86
CD36 CD36 molecule (thrombospondin receptor)
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLEC7A C-type lectin domain family 7, member A
COCH cochlin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTBP2 C-terminal binding protein 2
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
EDNRA endothelin receptor type A
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF5A eukaryotic translation initiation factor 5A
FAM46A family with sequence similarity 46, member A
FBN2 fibrillin 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD2 FXYD domain containing ion transport regulator 2
GGT1 gamma-glutamyltransferase 1
GPM6B glycoprotein M6B
GUSB glucuronidase, beta
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
KAZN kazrin, periplakin interacting protein
KIAA1033 KIAA1033
KLK11 kallikrein-related peptidase 11
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPAR6 lysophosphatidic acid receptor 6
LY86 lymphocyte antigen 86
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MSMB microseminoprotein, beta-
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PDZK1IP1 PDZK1 interacting protein 1
PGLS 6-phosphogluconolactonase
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PLXNC1 plexin C1
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RET ret proto-oncogene
RNASE6 ribonuclease, RNase A family, k6
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS11 ribosomal protein S11
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNX13 sorting nexin 13
SOD3 superoxide dismutase 3, extracellular
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TARP TCR gamma alternate reading frame protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP4 TIMP metallopeptidase inhibitor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOB2 transducer of ERBB2, 2
UBE2I ubiquitin-conjugating enzyme E2I
VCAN versican
VLDLR very low density lipoprotein receptor
ZIC1 Zic family member 1