BRD-K23875128_Rho kinase inhibitor III [rockout]_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AIM1 absent in melanoma 1
ASPN asporin
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CAPN2 calpain 2, (m/II) large subunit
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL10A1 collagen, type X, alpha 1
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CYB561 cytochrome b561
DFNA5 deafness, autosomal dominant 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EMP1 epithelial membrane protein 1
EZR ezrin
FAP fibroblast activation protein, alpha
FKBP5 FK506 binding protein 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
KLF9 Kruppel-like factor 9
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
OSBPL1A oxysterol binding protein-like 1A
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM1 PDZ and LIM domain 1
PER1 period circadian clock 1
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PSCA prostate stem cell antigen
RGS2 regulator of G-protein signaling 2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SAP30 Sin3A-associated protein, 30kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STOM stomatin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
ARL4C ADP-ribosylation factor-like 4C
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DST dystonin
DUSP4 dual specificity phosphatase 4
FAM46A family with sequence similarity 46, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
HHEX hematopoietically expressed homeobox
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KIAA0226L KIAA0226-like
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
NDRG4 NDRG family member 4
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRG1 neuregulin 1
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SSFA2 sperm specific antigen 2
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNNT1 troponin T type 1 (skeletal, slow)
VAV3 vav 3 guanine nucleotide exchange factor
WT1 Wilms tumor 1