BRD-K23875128_Rho kinase inhibitor III [rockout]_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCL8 chemokine (C-C motif) ligand 8
CDK14 cyclin-dependent kinase 14
CFB complement factor B
CFD complement factor D (adipsin)
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT4 DNA-damage-inducible transcript 4
DHDDS dehydrodolichyl diphosphate synthase
EMP1 epithelial membrane protein 1
FABP4 fatty acid binding protein 4, adipocyte
GJA1 gap junction protein, alpha 1, 43kDa
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSTA1 glutathione S-transferase alpha 1
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
JADE2 jade family PHD finger 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP3 lysosomal-associated membrane protein 3
MPZL2 myelin protein zero-like 2
MX1 MX dynamin-like GTPase 1
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PON3 paraoxonase 3
RGCC regulator of cell cycle
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
CCL21 chemokine (C-C motif) ligand 21
FABP7 fatty acid binding protein 7, brain
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAS7 growth arrest-specific 7
IGFBP3 insulin-like growth factor binding protein 3
KRT14 keratin 14, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LMO4 LIM domain only 4
LPIN1 lipin 1
MAGEA12 melanoma antigen family A12
MBNL2 muscleblind-like splicing regulator 2
MOK MOK protein kinase
MSX1 msh homeobox 1
TMEM2 transmembrane protein 2
TPM1 tropomyosin 1 (alpha)