BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AREG amphiregulin
CD163 CD163 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CPM carboxypeptidase M
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EPHA4 EPH receptor A4
F13A1 coagulation factor XIII, A1 polypeptide
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GAGE3 G antigen 3
GLA galactosidase, alpha
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLK5 kallikrein-related peptidase 5
KRT1 keratin 1, type II
LHX2 LIM homeobox 2
LOC100272216 uncharacterized LOC100272216
MAGEA3 melanoma antigen family A3
NQO1 NAD(P)H dehydrogenase, quinone 1
OAT ornithine aminotransferase
PHGDH phosphoglycerate dehydrogenase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
RAB20 RAB20, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RBM47 RNA binding motif protein 47
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SEPP1 selenoprotein P, plasma, 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BAX BCL2-associated X protein
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD81 CD81 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC3 chloride intracellular channel 3
COL9A3 collagen, type IX, alpha 3
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
FAS Fas cell surface death receptor
FGFR4 fibroblast growth factor receptor 4
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
LIPG lipase, endothelial
MARCKSL1 MARCKS-like 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PPIB peptidylprolyl isomerase B (cyclophilin B)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SALL1 spalt-like transcription factor 1
SAMHD1 SAM domain and HD domain 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
VCAM1 vascular cell adhesion molecule 1
VEGFC vascular endothelial growth factor C