BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AMPD3 adenosine monophosphate deaminase 3
ANO10 anoctamin 10
CADM1 cell adhesion molecule 1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL4A5 collagen, type IV, alpha 5
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRISP3 cysteine-rich secretory protein 3
CXCR4 chemokine (C-X-C motif) receptor 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
GPM6B glycoprotein M6B
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAPTM5 lysosomal protein transmembrane 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR1 lysophosphatidic acid receptor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MYLK myosin light chain kinase
NLRP2 NLR family, pyrin domain containing 2
OGFRL1 opioid growth factor receptor-like 1
PEG3 paternally expressed 3
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
REG1A regenerating islet-derived 1 alpha
RRAD Ras-related associated with diabetes
SCG5 secretogranin V
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPC surfactant protein C
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM38 tripartite motif containing 38
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WNT5A wingless-type MMTV integration site family, member 5A
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAB39 calcium binding protein 39
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDCA4 cell division cycle associated 4
CIAPIN1 cytokine induced apoptosis inhibitor 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CPNE1 copine I
CYC1 cytochrome c-1
DERA deoxyribose-phosphate aldolase (putative)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DYNLRB1 dynein, light chain, roadblock-type 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EMP3 epithelial membrane protein 3
ERLIN1 ER lipid raft associated 1
ESD esterase D
FAM3C family with sequence similarity 3, member C
FXYD3 FXYD domain containing ion transport regulator 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HAT1 histone acetyltransferase 1
HOXA10 homeobox A10
IER3 immediate early response 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
LGALS1 lectin, galactoside-binding, soluble, 1
MMP7 matrix metallopeptidase 7
MRPL22 mitochondrial ribosomal protein L22
MRPL23 mitochondrial ribosomal protein L23
MRPS12 mitochondrial ribosomal protein S12
NPM3 nucleophosmin/nucleoplasmin 3
PCCB propionyl CoA carboxylase, beta polypeptide
PCDH9 protocadherin 9
PHB prohibitin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRMT1 protein arginine methyltransferase 1
PRNP prion protein
PTPN3 protein tyrosine phosphatase, non-receptor type 3
RGS2 regulator of G-protein signaling 2
SCAND1 SCAN domain containing 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SGK1 serum/glucocorticoid regulated kinase 1
SLC35F2 solute carrier family 35, member F2
SNX10 sorting nexin 10
SPATA5L1 spermatogenesis associated 5-like 1
SRPX sushi-repeat containing protein, X-linked
TBCB tubulin folding cofactor B
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM9SF3 transmembrane 9 superfamily member 3
TMEM176B transmembrane protein 176B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
UQCRC2 ubiquinol-cytochrome c reductase core protein II
VDAC1 voltage-dependent anion channel 1
WDR61 WD repeat domain 61