BRD-K23149109_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K23149109_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
COL5A1 collagen, type V, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
EGLN1 egl-9 family hypoxia-inducible factor 1
EMP1 epithelial membrane protein 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM3A lysine (K)-specific demethylase 3A
LOX lysyl oxidase
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDLIM4 PDZ and LIM domain 4
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTX3 pentraxin 3, long
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPAG4 sperm associated antigen 4
THBS1 thrombospondin 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
VCAN versican
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
DCK deoxycytidine kinase
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
LXN latexin
LYZ lysozyme
MAP7 microtubule-associated protein 7
METRN meteorin, glial cell differentiation regulator
MID1 midline 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PAWR PRKC, apoptosis, WT1, regulator
PEBP1 phosphatidylethanolamine binding protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PWP1 PWP1 homolog (S. cerevisiae)
QPRT quinolinate phosphoribosyltransferase
RGS5 regulator of G-protein signaling 5
S100A10 S100 calcium binding protein A10
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TARBP1 TAR (HIV-1) RNA binding protein 1
TMEM14A transmembrane protein 14A