BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

41 genes differentially expressed following the BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CDCA8 cell division cycle associated 8
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
HMG20B high mobility group 20B
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
RHOBTB3 Rho-related BTB domain containing 3
SPAG5 sperm associated antigen 5
TIMP3 TIMP metallopeptidase inhibitor 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TTK TTK protein kinase

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CLDN18 claudin 18
FHL1 four and a half LIM domains 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
JAG1 jagged 1
PRNP prion protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100A8 S100 calcium binding protein A8
TFPI2 tissue factor pathway inhibitor 2
ZFP36L2 ZFP36 ring finger protein-like 2