BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
COL11A1 collagen, type XI, alpha 1
CP ceruloplasmin (ferroxidase)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
GOLGA8B golgin A8 family, member B
HIST2H2BE histone cluster 2, H2be
IL7R interleukin 7 receptor
JAG1 jagged 1
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCAM1 neural cell adhesion molecule 1
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
S100A8 S100 calcium binding protein A8
SFRP4 secreted frizzled-related protein 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TP53I3 tumor protein p53 inducible protein 3
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNA2 cyclin A2
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GTF2H5 general transcription factor IIH, polypeptide 5
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
MAP7 microtubule-associated protein 7
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NPR3 natriuretic peptide receptor 3
NXT2 nuclear transport factor 2-like export factor 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TMEM14A transmembrane protein 14A
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
ZWINT ZW10 interacting kinetochore protein