BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CBX1 chromobox homolog 1
CELF2 CUGBP, Elav-like family member 2
EDNRB endothelin receptor type B
EPS8 epidermal growth factor receptor pathway substrate 8
FAM117A family with sequence similarity 117, member A
HNMT histamine N-methyltransferase
HOXD1 homeobox D1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
ITGB1BP1 integrin beta 1 binding protein 1
KANK1 KN motif and ankyrin repeat domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP1B microtubule-associated protein 1B
NCAM1 neural cell adhesion molecule 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
PSAT1 phosphoserine aminotransferase 1
PVRL3 poliovirus receptor-related 3
RAB31 RAB31, member RAS oncogene family
RBKS ribokinase
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RGS2 regulator of G-protein signaling 2
S100A10 S100 calcium binding protein A10
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SLC16A6 solute carrier family 16, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBC1D4 TBC1 domain family, member 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXNIP thioredoxin interacting protein
VCAN versican
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ADA adenosine deaminase
ADM adrenomedullin
ANXA1 annexin A1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
C2CD2 C2 calcium-dependent domain containing 2
CCND2 cyclin D2
CYBB cytochrome b-245, beta polypeptide
DLD dihydrolipoamide dehydrogenase
DNTT DNA nucleotidylexotransferase
EMP1 epithelial membrane protein 1
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
JAG1 jagged 1
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEOX2 mesenchyme homeobox 2
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PITX1 paired-like homeodomain 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RRM2 ribonucleotide reductase M2
SORBS3 sorbin and SH3 domain containing 3
SUB1 SUB1 homolog (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2