BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA6 annexin A6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BAX BCL2-associated X protein
CCND2 cyclin D2
CCNG1 cyclin G1
CD14 CD14 molecule
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CHRDL1 chordin-like 1
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DRAM1 DNA-damage regulated autophagy modulator 1
DSE dermatan sulfate epimerase
EPHA2 EPH receptor A2
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FDXR ferredoxin reductase
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
GBP2 guanylate binding protein 2, interferon-inducible
GPM6A glycoprotein M6A
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
IGFBP6 insulin-like growth factor binding protein 6
IL32 interleukin 32
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
MSRB2 methionine sulfoxide reductase B2
NEBL nebulette
NINJ1 ninjurin 1
PGLS 6-phosphogluconolactonase
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS4 regulator of G-protein signaling 4
RPS27L ribosomal protein S27-like
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFN stratifin
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX9 SRY (sex determining region Y)-box 9
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SVIL supervillin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADM adrenomedullin
AEBP1 AE binding protein 1
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
DCK deoxycytidine kinase
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DNM1L dynamin 1-like
FAM60A family with sequence similarity 60, member A
FAM69A family with sequence similarity 69, member A
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL1R1 interleukin 1 receptor, type I
LUM lumican
MED21 mediator complex subunit 21
PTPRK protein tyrosine phosphatase, receptor type, K
RAD51AP1 RAD51 associated protein 1
REEP1 receptor accessory protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TSPAN12 tetraspanin 12