BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ASS1 argininosuccinate synthase 1
BAX BCL2-associated X protein
BTG3 BTG family, member 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
CRABP2 cellular retinoic acid binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFHC1 EF-hand domain (C-terminal) containing 1
FBXL12 F-box and leucine-rich repeat protein 12
FDXR ferredoxin reductase
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IER5 immediate early response 5
INHBB inhibin, beta B
IRF9 interferon regulatory factor 9
KRT14 keratin 14, type I
MDK midkine (neurite growth-promoting factor 2)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX2 neuronal pentraxin II
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNB2 plexin B2
RGCC regulator of cell cycle
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC35G2 solute carrier family 35, member G2
STC2 stanniocalcin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AMD1 adenosylmethionine decarboxylase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CDC20 cell division cycle 20
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL4A2 collagen, type IV, alpha 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSH cathepsin H
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
E2F2 E2F transcription factor 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM134B family with sequence similarity 134, member B
FSTL1 follistatin-like 1
GOLM1 golgi membrane protein 1
GSAP gamma-secretase activating protein
GSTP1 glutathione S-transferase pi 1
IFITM1 interferon induced transmembrane protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
LUM lumican
MATN2 matrilin 2
MBP myelin basic protein
MSH6 mutS homolog 6
MYH10 myosin, heavy chain 10, non-muscle
OAT ornithine aminotransferase
PARD3 par-3 family cell polarity regulator
RBM47 RNA binding motif protein 47
RPS11 ribosomal protein S11
RPS5 ribosomal protein S5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D4 TBC1 domain family, member 4
TJP2 tight junction protein 2
ZNF22 zinc finger protein 22
Funding