BRD-K22215695_1-(4-methylbenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

43 genes differentially expressed following the BRD-K22215695_1-(4-methylbenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKAP12 A kinase (PRKA) anchor protein 12
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
CORO1A coronin, actin binding protein, 1A
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
G0S2 G0/G1 switch 2
INSM1 insulinoma-associated 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
NCAM1 neural cell adhesion molecule 1
NEBL nebulette
NRCAM neuronal cell adhesion molecule
PAM peptidylglycine alpha-amidating monooxygenase
PEG10 paternally expressed 10
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ATP10A ATPase, class V, type 10A
BAMBI BMP and activin membrane-bound inhibitor
CHPT1 choline phosphotransferase 1
COMP cartilage oligomeric matrix protein
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
GLRX glutaredoxin (thioltransferase)
GRAMD3 GRAM domain containing 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KLF4 Kruppel-like factor 4 (gut)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK6 mitogen-activated protein kinase 6
MCOLN1 mucolipin 1
PKM pyruvate kinase, muscle
PRDX1 peroxiredoxin 1
SEPP1 selenoprotein P, plasma, 1
SIDT2 SID1 transmembrane family, member 2
VGLL4 vestigial-like family member 4