BRD-K22215695_1-(4-methylbenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K22215695_1-(4-methylbenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BCL2A1 BCL2-related protein A1
CA12 carbonic anhydrase XII
CFLAR CASP8 and FADD-like apoptosis regulator
CKLF chemokine-like factor
CNPY3 canopy FGF signaling regulator 3
CRABP1 cellular retinoic acid binding protein 1
CYBRD1 cytochrome b reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPN2 epsin 2
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FBXL12 F-box and leucine-rich repeat protein 12
FBXO11 F-box protein 11
FKBP1B FK506 binding protein 1B, 12.6 kDa
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LRRC17 leucine rich repeat containing 17
MLF1 myeloid leukemia factor 1
MLPH melanophilin
MNAT1 MNAT CDK-activating kinase assembly factor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MT2A metallothionein 2A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAM peptidylglycine alpha-amidating monooxygenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
S100A11 S100 calcium binding protein A11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOAT1 sterol O-acyltransferase 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AIM1 absent in melanoma 1
ANKRD10 ankyrin repeat domain 10
ANKRD28 ankyrin repeat domain 28
AUTS2 autism susceptibility candidate 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
CUL1 cullin 1
DUSP22 dual specificity phosphatase 22
ELANE elastase, neutrophil expressed
FASTKD5 FAST kinase domains 5
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GOLGA8A golgin A8 family, member A
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
H3F3B H3 histone, family 3B (H3.3B)
HK1 hexokinase 1
HSPA1A heat shock 70kDa protein 1A
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
LEPROTL1 leptin receptor overlapping transcript-like 1
LINC00341 long intergenic non-protein coding RNA 341
LXN latexin
MAK16 MAK16 homolog (S. cerevisiae)
MDFIC MyoD family inhibitor domain containing
MLXIP MLX interacting protein
MMP9 matrix metallopeptidase 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP50 nucleoporin 50kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX3 pre-B-cell leukemia homeobox 3
PDS5A PDS5 cohesin associated factor A
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRK protein tyrosine phosphatase, receptor type, K
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRP1B ribosomal RNA processing 1B
RUNX3 runt-related transcription factor 3
SCO2 SCO2 cytochrome c oxidase assembly protein
SESN1 sestrin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE3C ubiquitin protein ligase E3C