BRD-K22096725_ALW-II-49-7_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K22096725_ALW-II-49-7_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT1 angiopoietin 1
ANXA3 annexin A3
CAPN2 calpain 2, (m/II) large subunit
CCL19 chemokine (C-C motif) ligand 19
CD58 CD58 molecule
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL14A1 collagen, type XIV, alpha 1
CST1 cystatin SN
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
HOPX HOP homeobox
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LRP10 low density lipoprotein receptor-related protein 10
MYOF myoferlin
NEFH neurofilament, heavy polypeptide
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPARG peroxisome proliferator-activated receptor gamma
PTRF polymerase I and transcript release factor
RGS1 regulator of G-protein signaling 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
TIMP3 TIMP metallopeptidase inhibitor 3
TM9SF3 transmembrane 9 superfamily member 3
TOMM34 translocase of outer mitochondrial membrane 34

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ARMCX2 armadillo repeat containing, X-linked 2
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CNN3 calponin 3, acidic
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCT dopachrome tautomerase
DEFB1 defensin, beta 1
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
GPC3 glypican 3
GPM6B glycoprotein M6B
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
LOC100505650 uncharacterized LOC100505650
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
NREP neuronal regeneration related protein
NSG1 neuron specific gene family member 1
PEG3 paternally expressed 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PRDX2 peroxiredoxin 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SPRR1A small proline-rich protein 1A
TMEM97 transmembrane protein 97
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)