BRD-K22006123_4-morpholino-N-phenyl-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act03_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K22006123_4-morpholino-N-phenyl-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act03_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHNAK AHNAK nucleoprotein
BCL2A1 BCL2-related protein A1
CD300A CD300a molecule
CDC20 cell division cycle 20
CLGN calmegin
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CRABP2 cellular retinoic acid binding protein 2
CREM cAMP responsive element modulator
CRIP2 cysteine-rich protein 2
CTSB cathepsin B
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
DCT dopachrome tautomerase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DSP desmoplakin
DUSP22 dual specificity phosphatase 22
DUSP5 dual specificity phosphatase 5
EMP3 epithelial membrane protein 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADS1 fatty acid desaturase 1
FAM162A family with sequence similarity 162, member A
FTH1 ferritin, heavy polypeptide 1
GM2A GM2 ganglioside activator
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLGA8A golgin A8 family, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HEBP1 heme binding protein 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
IL1RN interleukin 1 receptor antagonist
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA1598
KLF6 Kruppel-like factor 6
MAPK13 mitogen-activated protein kinase 13
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MLANA melan-A
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PIP prolactin-induced protein
PLIN2 perilipin 2
RAB29 RAB29, member RAS oncogene family
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC1 syndecan 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A6 solute carrier family 16, member 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TYR tyrosinase
TYRP1 tyrosinase-related protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CYBB cytochrome b-245, beta polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FRY furry homolog (Drosophila)
FZD7 frizzled class receptor 7
GBP1 guanylate binding protein 1, interferon-inducible
GMFG glia maturation factor, gamma
GRIA2 glutamate receptor, ionotropic, AMPA 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
MTCL1 microtubule crosslinking factor 1
OXTR oxytocin receptor
PTN pleiotrophin
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
TGFB1 transforming growth factor, beta 1
TPM1 tropomyosin 1 (alpha)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF512B zinc finger protein 512B