BRD-K21680192_mitoxantrone_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

303 genes differentially expressed following the BRD-K21680192_mitoxantrone_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ADAM12 ADAM metallopeptidase domain 12
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ADK adenosine kinase
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAALC brain and acute leukemia, cytoplasmic
BACE2 beta-site APP-cleaving enzyme 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD48 CD48 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC7A C-type lectin domain family 7, member A
CLGN calmegin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CTSK cathepsin K
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNTT DNA nucleotidylexotransferase
DRAM1 DNA-damage regulated autophagy modulator 1
DSE dermatan sulfate epimerase
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFL6 EGF-like-domain, multiple 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GAS6 growth arrest-specific 6
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GM2A GM2 ganglioside activator
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HCAR3 hydroxycarboxylic acid receptor 3
HMGN5 high mobility group nucleosome binding domain 5
HTRA1 HtrA serine peptidase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
ITGAV integrin, alpha V
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LAGE3 L antigen family, member 3
LAMP3 lysosomal-associated membrane protein 3
LGMN legumain
LOC100505650 uncharacterized LOC100505650
LRRC15 leucine rich repeat containing 15
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MAOA monoamine oxidase A
MCOLN1 mucolipin 1
MCUR1 mitochondrial calcium uniporter regulator 1
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MXD4 MAX dimerization protein 4
MXRA5 matrix-remodelling associated 5
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NEBL nebulette
NEFL neurofilament, light polypeptide
NGRN neugrin, neurite outgrowth associated
NLRP2 NLR family, pyrin domain containing 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPR3 natriuretic peptide receptor 3
NTS neurotensin
ODC1 ornithine decarboxylase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLS3 plastin 3
PON2 paraoxonase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROS1 protein S (alpha)
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP5 receptor accessory protein 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RHOQ ras homolog family member Q
RPL37A ribosomal protein L37a
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3YL1 SH3 and SYLF domain containing 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP6 syntaxin binding protein 6 (amisyn)
SULF1 sulfatase 1
TCF4 transcription factor 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THY1 Thy-1 cell surface antigen
TKTL1 transketolase-like 1
TMEM110 transmembrane protein 110
TMEM45A transmembrane protein 45A
TP53TG1 TP53 target 1 (non-protein coding)
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL5 acyl-CoA synthetase long-chain family member 5
ADNP activity-dependent neuroprotector homeobox
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARF6 ADP-ribosylation factor 6
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASXL2 additional sex combs like transcriptional regulator 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
CALML5 calmodulin-like 5
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK7 cyclin-dependent kinase 7
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHEK2 checkpoint kinase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COA3 cytochrome c oxidase assembly factor 3
CRISP3 cysteine-rich secretory protein 3
CSNK1D casein kinase 1, delta
CST1 cystatin SN
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETNK1 ethanolamine kinase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GOLT1B golgi transport 1B
GPATCH8 G patch domain containing 8
HLA-B major histocompatibility complex, class I, B
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD14 potassium channel tetramerization domain containing 14
KCTD5 potassium channel tetramerization domain containing 5
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
KLK5 kallikrein-related peptidase 5
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KYNU kynureninase
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LTF lactotransferrin
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MELK maternal embryonic leucine zipper kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDLIM4 PDZ and LIM domain 4
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLN phospholamban
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
RBM15 RNA binding motif protein 15
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RET ret proto-oncogene
RNMT RNA (guanine-7-) methyltransferase
RRM2 ribonucleotide reductase M2
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP4 SH3-domain binding protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STX3 syntaxin 3
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM2 translocation associated membrane protein 2
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)